Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
lhx1bLIM class homeodomain protein. (402 aa)    
Predicted Functional Partners:
ccnk
Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
    
   0.747
nkx2.1
NK2 homeobox 1b.
   
 
 0.588
ldb3b
LIM domain-binding 3b.
    
 
 0.568
pax2b
Paired box 2b.
   
 
 0.523
emx2
Empty spiracles homeobox 2.
    
 
 0.519
ldb1a
LIM domain-binding protein 1-A; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
    
 
 0.518
ldb2b
LIM-domain binding factor 2b.
    
 
 0.518
ldb2a
LIM domain-binding 2a.
    
 
 0.518
ldb1b
LIM domain-binding protein 1-A.
    
 
 0.518
pax2a
Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
    
 
 0.486
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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