Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
chataCholine O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase family. (637 aa)    
Predicted Functional Partners:
slc18a3a
Probable vesicular acetylcholine transporter-A; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family.
 
 
 
 0.997
slc18a3b
Probable vesicular acetylcholine transporter-B; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family.
 
 
 
 0.992
gpcpd1
Glycerophosphocholine phosphodiesterase 1.
   
 
 0.955
phospho1
Probable phosphatase phospho1; Probable phosphatase, involved in bone mineralization. Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
     
 0.955
chka
Choline kinase alpha.
   
 
 0.952
chkb
Choline kinase beta.
     
 0.952
ache
Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
     
 0.932
F1QHP3_DANRE
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
     
 0.909
LOC100334697
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
     
 0.868
phospho2
Phosphatase, orphan 2.
     
 0.855
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: medium (48%) [HD]