nkx2.1 protein (Danio rerio) - STRING interaction network

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Score

nkx2.1

NK2 homeobox 1b. (346 aa)

Predicted Functional Partners:

lhx6

0.827

shha

0.805

pax8

0.794

foxa2

0.776

foxg1a

0.772

tshr

0.720

slc5a5

0.720

foxa1

0.712

tg

0.706

six3b

0.702

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
foxa1	nkx2.1	ENSDARP00000137654	ENSDARP00000025546	Forkhead box A1.	NK2 homeobox 1b.	0.712
foxa1	shha	ENSDARP00000137654	ENSDARP00000125090	Forkhead box A1.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.595
foxa2	nkx2.1	ENSDARP00000007827	ENSDARP00000025546	Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system.	NK2 homeobox 1b.	0.776
foxa2	shha	ENSDARP00000007827	ENSDARP00000125090	Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.804
foxa2	six3b	ENSDARP00000007827	ENSDARP00000071625	Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system.	Sine oculis homeobox homolog 3b.	0.422
foxg1a	lhx6	ENSDARP00000094979	ENSDARP00000017657	Forkhead box G1a.	LIM homeobox 6.	0.672
foxg1a	nkx2.1	ENSDARP00000094979	ENSDARP00000025546	Forkhead box G1a.	NK2 homeobox 1b.	0.772
foxg1a	shha	ENSDARP00000094979	ENSDARP00000125090	Forkhead box G1a.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.742
foxg1a	six3b	ENSDARP00000094979	ENSDARP00000071625	Forkhead box G1a.	Sine oculis homeobox homolog 3b.	0.758
lhx6	foxg1a	ENSDARP00000017657	ENSDARP00000094979	LIM homeobox 6.	Forkhead box G1a.	0.672
lhx6	nkx2.1	ENSDARP00000017657	ENSDARP00000025546	LIM homeobox 6.	NK2 homeobox 1b.	0.827
lhx6	shha	ENSDARP00000017657	ENSDARP00000125090	LIM homeobox 6.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.622
lhx6	six3b	ENSDARP00000017657	ENSDARP00000071625	LIM homeobox 6.	Sine oculis homeobox homolog 3b.	0.425
nkx2.1	foxa1	ENSDARP00000025546	ENSDARP00000137654	NK2 homeobox 1b.	Forkhead box A1.	0.712
nkx2.1	foxa2	ENSDARP00000025546	ENSDARP00000007827	NK2 homeobox 1b.	Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system.	0.776
nkx2.1	foxg1a	ENSDARP00000025546	ENSDARP00000094979	NK2 homeobox 1b.	Forkhead box G1a.	0.772
nkx2.1	lhx6	ENSDARP00000025546	ENSDARP00000017657	NK2 homeobox 1b.	LIM homeobox 6.	0.827
nkx2.1	pax8	ENSDARP00000025546	ENSDARP00000033414	NK2 homeobox 1b.	Paired box 8.	0.794
nkx2.1	shha	ENSDARP00000025546	ENSDARP00000125090	NK2 homeobox 1b.	Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).	0.805
nkx2.1	six3b	ENSDARP00000025546	ENSDARP00000071625	NK2 homeobox 1b.	Sine oculis homeobox homolog 3b.	0.702

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