Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC110438944Galanin receptor 2a; Receptor for the hormone galanin. Receptor for the hormones spexin-1 and spexin-2. (363 aa)    
Predicted Functional Partners:
spx
Spexin prohormone 1; Plays a role in the regulation of food intake and energy metabolism. May also be involved in suppressing the anxiety response by promoting the expression of serotonin-related genes such as fev, tph2 and slc6a4a. Belongs to the spexin family.
   
 0.996
galn
Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1 (galr1a and galr1b) and GALR2 (galr2a and galr2b). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
    
 0.995
si:rp71-1c10.8
Si:rp71-1c10.8.
     
 0.881
galr1a
Galanin receptor 1a; Belongs to the G-protein coupled receptor 1 family.
     
0.789
hsd17b1
Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.717
galr1b
Galanin receptor 1b; Belongs to the G-protein coupled receptor 1 family.
     
0.665
agrp
Agouti-related neuropeptide.
    
 0.630
pomca
Pro-opiomelanocortin protein.
    
 0.623
cga
Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.
   
 
 0.581
apln
Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity).
    
 0.579
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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