STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dscc1Sister chromatid cohesion protein DCC1; Loads pcna onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion (By similarity). (391 aa)    
Predicted Functional Partners:
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae).
   
 0.999
chtf18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae).
   
 
 0.995
rfc3
Replication factor C (Activator 1) 3.
   
 0.995
rfc5
Replication factor C (activator 1) 5.
   
 0.983
rfc2
Replication factor C (activator 1) 2.
   
 0.983
rfc4
Replication factor C (activator 1) 4.
   
 0.952
pole
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 
 0.948
prim1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 
 0.898
pola1
DNA polymerase.
   
 0.898
prim2
DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.
   
 
 0.882
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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