Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dscc1Sister chromatid cohesion protein DCC1; Loads pcna onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion (By similarity). (391 aa)    
Predicted Functional Partners:
chtf18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae).
   
 0.998
chtf8
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae).
   
 0.997
rfc2
Replication factor C (activator 1) 2.
   
 
 0.996
rfc3
Replication factor C (Activator 1) 3.
   
 
 0.995
rfc5
Replication factor C (activator 1) 5.
   
 
 0.993
rfc4
Replication factor C (activator 1) 4.
   
 
 0.993
tipin
TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required fin the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity).
   
 
 0.957
atad5b
ATPase family AAA domain-containing 5b.
   
 
 0.946
prim1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
  
 0.926
smc3
Structural maintenance of chromosomes protein.
   
 
 0.911
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.