Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hsf4Heat shock transcription factor 4. (286 aa)    
Predicted Functional Partners:
crybb1
Crystallin, beta B1; Belongs to the beta/gamma-crystallin family.
   
  
 0.740
crybb2
Crystallin, beta B2; Belongs to the beta/gamma-crystallin family.
   
  
 0.726
mipb
Major intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
 
 0.715
cryaa
Crystallin, alpha A; Belongs to the small heat shock protein (HSP20) family.
   
 
 0.711
BFSP1
Beaded filament structural protein 1.
      
 0.687
cryaba
Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family.
    
 
 0.675
crygn2
Gamma-crystallin N-B; Crystallins are the dominant structural components of the vertebrate eye lens.
   
  
 0.665
cryba1l1
Crystallin, beta A1,-like 1; Belongs to the beta/gamma-crystallin family.
      
 0.661
hspbp1
HSPA (heat shock 70kDa)-binding protein, cytoplasmic cochaperone 1.
   
 
 0.660
hsbp1b
Heat shock factor-binding protein 1b.
    
 0.642
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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