| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ash2l | poc1b | ENSDARP00000079466 | ENSDARP00000026057 | Ash2-like, histone lysine methyltransferase complex subunit. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.759 |
| ash2l | rbbp5 | ENSDARP00000079466 | ENSDARP00000061774 | Ash2-like, histone lysine methyltransferase complex subunit. | Retinoblastoma-binding protein 5. | 0.999 |
| c1galt1c1 | gcnt3 | ENSDARP00000052788 | ENSDARP00000079686 | C1GALT1-specific chaperone 1. | Glucosaminyl (N-acetyl) transferase 3, mucin type. | 0.972 |
| c1galt1c1 | poc1b | ENSDARP00000052788 | ENSDARP00000026057 | C1GALT1-specific chaperone 1. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.832 |
| cep135 | cspp1 | ENSDARP00000035272 | ENSDARP00000137070 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | Centrosome and spindle pole-associated protein 1a. | 0.486 |
| cep135 | plk4 | ENSDARP00000035272 | ENSDARP00000043865 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | 0.958 |
| cep135 | poc1b | ENSDARP00000035272 | ENSDARP00000026057 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.798 |
| cep135 | poc5 | ENSDARP00000035272 | ENSDARP00000121737 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | POC5 centriolar protein homolog (Chlamydomonas). | 0.493 |
| cep135 | sass6 | ENSDARP00000035272 | ENSDARP00000075634 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). | 0.967 |
| cspp1 | cep135 | ENSDARP00000137070 | ENSDARP00000035272 | Centrosome and spindle pole-associated protein 1a. | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | 0.486 |
| cspp1 | poc1b | ENSDARP00000137070 | ENSDARP00000026057 | Centrosome and spindle pole-associated protein 1a. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.806 |
| fam161a | poc1b | ENSDARP00000110366 | ENSDARP00000026057 | FAM161 centrosomal protein A. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.826 |
| fam161a | poc5 | ENSDARP00000110366 | ENSDARP00000121737 | FAM161 centrosomal protein A. | POC5 centriolar protein homolog (Chlamydomonas). | 0.709 |
| gcnt3 | c1galt1c1 | ENSDARP00000079686 | ENSDARP00000052788 | Glucosaminyl (N-acetyl) transferase 3, mucin type. | C1GALT1-specific chaperone 1. | 0.972 |
| gcnt3 | poc1b | ENSDARP00000079686 | ENSDARP00000026057 | Glucosaminyl (N-acetyl) transferase 3, mucin type. | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.845 |
| plk4 | cep135 | ENSDARP00000043865 | ENSDARP00000035272 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for cep250 at the centriole (By similarity). Belongs to the CEP135/TSGA10 family. | 0.958 |
| plk4 | poc1b | ENSDARP00000043865 | ENSDARP00000026057 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | 0.782 |
| plk4 | poc5 | ENSDARP00000043865 | ENSDARP00000121737 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | POC5 centriolar protein homolog (Chlamydomonas). | 0.472 |
| plk4 | sass6 | ENSDARP00000043865 | ENSDARP00000075634 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). | 0.999 |
| poc1b | ash2l | ENSDARP00000026057 | ENSDARP00000079466 | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. | Ash2-like, histone lysine methyltransferase complex subunit. | 0.759 |
