node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ephb1 | foxd1 | ENSDARP00000111570 | ENSDARP00000043340 | EPH receptor B1. | Forkhead box D1. | 0.575 |
ephb1 | isl2a | ENSDARP00000111570 | ENSDARP00000020636 | EPH receptor B1. | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | 0.630 |
ephb1 | zic2a | ENSDARP00000111570 | ENSDARP00000026131 | EPH receptor B1. | ZIC family member 2 (Odd-paired homolog, Drosophila), A. | 0.812 |
foxd1 | ephb1 | ENSDARP00000043340 | ENSDARP00000111570 | Forkhead box D1. | EPH receptor B1. | 0.575 |
foxd1 | pax2a | ENSDARP00000043340 | ENSDARP00000071466 | Forkhead box D1. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.594 |
foxd1 | shha | ENSDARP00000043340 | ENSDARP00000125090 | Forkhead box D1. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.668 |
foxd1 | vax1 | ENSDARP00000043340 | ENSDARP00000039283 | Forkhead box D1. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.459 |
foxd1 | zic2a | ENSDARP00000043340 | ENSDARP00000026131 | Forkhead box D1. | ZIC family member 2 (Odd-paired homolog, Drosophila), A. | 0.557 |
isl2a | ephb1 | ENSDARP00000020636 | ENSDARP00000111570 | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | EPH receptor B1. | 0.630 |
isl2a | pax2a | ENSDARP00000020636 | ENSDARP00000071466 | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | 0.584 |
isl2a | shha | ENSDARP00000020636 | ENSDARP00000125090 | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.519 |
isl2a | zic2a | ENSDARP00000020636 | ENSDARP00000026131 | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | ZIC family member 2 (Odd-paired homolog, Drosophila), A. | 0.589 |
pax2a | foxd1 | ENSDARP00000071466 | ENSDARP00000043340 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Forkhead box D1. | 0.594 |
pax2a | isl2a | ENSDARP00000071466 | ENSDARP00000020636 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Insulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. | 0.584 |
pax2a | shha | ENSDARP00000071466 | ENSDARP00000125090 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.858 |
pax2a | six3a | ENSDARP00000071466 | ENSDARP00000075254 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sine oculis homeobox homolog 3a. | 0.783 |
pax2a | six3b | ENSDARP00000071466 | ENSDARP00000071625 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Sine oculis homeobox homolog 3b. | 0.777 |
pax2a | vax1 | ENSDARP00000071466 | ENSDARP00000039283 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. | 0.868 |
pax2a | zic2a | ENSDARP00000071466 | ENSDARP00000026131 | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. | ZIC family member 2 (Odd-paired homolog, Drosophila), A. | 0.578 |
shha | foxd1 | ENSDARP00000125090 | ENSDARP00000043340 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | Forkhead box D1. | 0.668 |