node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
TCF24 | prdm9 | ENSDARP00000110569 | ENSDARP00000026323 | Transcription factor 24. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.680 |
ankrd31 | hormad1 | ENSDARP00000069125 | ENSDARP00000058887 | Ankyrin repeat domain 31. | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | 0.893 |
ankrd31 | prdm9 | ENSDARP00000069125 | ENSDARP00000026323 | Ankyrin repeat domain 31. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.727 |
ankrd31 | rec114 | ENSDARP00000069125 | ENSDARP00000115176 | Ankyrin repeat domain 31. | REC114 meiotic recombination protein. | 0.999 |
ankrd31 | spo11 | ENSDARP00000069125 | ENSDARP00000002837 | Ankyrin repeat domain 31. | SPO11 initiator of meiotic double stranded breaks. | 0.745 |
ash1l | camkmt | ENSDARP00000105655 | ENSDARP00000155968 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Calmodulin-lysine N-methyltransferase. | 0.698 |
ash1l | plod1a | ENSDARP00000105655 | ENSDARP00000077830 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a. | 0.662 |
ash1l | prdm9 | ENSDARP00000105655 | ENSDARP00000026323 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.673 |
ash1l | setd3 | ENSDARP00000105655 | ENSDARP00000005500 | Ash1 (absent, small, or homeotic)-like (Drosophila). | Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family. | 0.816 |
camkmt | ash1l | ENSDARP00000155968 | ENSDARP00000105655 | Calmodulin-lysine N-methyltransferase. | Ash1 (absent, small, or homeotic)-like (Drosophila). | 0.698 |
camkmt | plod1a | ENSDARP00000155968 | ENSDARP00000077830 | Calmodulin-lysine N-methyltransferase. | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a. | 0.900 |
camkmt | prdm9 | ENSDARP00000155968 | ENSDARP00000026323 | Calmodulin-lysine N-methyltransferase. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.663 |
cxxc1b | hormad1 | ENSDARP00000032784 | ENSDARP00000058887 | CXXC finger protein 1b. | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | 0.435 |
cxxc1b | prdm9 | ENSDARP00000032784 | ENSDARP00000026323 | CXXC finger protein 1b. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.781 |
cxxc1b | rec114 | ENSDARP00000032784 | ENSDARP00000115176 | CXXC finger protein 1b. | REC114 meiotic recombination protein. | 0.444 |
cxxc1b | spo11 | ENSDARP00000032784 | ENSDARP00000002837 | CXXC finger protein 1b. | SPO11 initiator of meiotic double stranded breaks. | 0.561 |
hormad1 | ankrd31 | ENSDARP00000058887 | ENSDARP00000069125 | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | Ankyrin repeat domain 31. | 0.893 |
hormad1 | cxxc1b | ENSDARP00000058887 | ENSDARP00000032784 | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | CXXC finger protein 1b. | 0.435 |
hormad1 | prdm9 | ENSDARP00000058887 | ENSDARP00000026323 | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] | 0.743 |
hormad1 | rec114 | ENSDARP00000058887 | ENSDARP00000115176 | HORMA domain-containing protein 1; Plays a key role in meiotic progression by ensuring that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search, promoting synaptonemal- complex formation independently and playing key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint. | REC114 meiotic recombination protein. | 0.883 |