Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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prdm9Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate [...] (853 aa)    
Predicted Functional Partners:
ash1l
Ash1 (absent, small, or homeotic)-like (Drosophila).
    
 0.938
setd2
SET domain-containing 2, histone lysine methyltransferase.
   
 0.933
dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
     
 0.926
setmar
SET domain and mariner transposase fusion protein.
    
 0.925
kmt2e
Lysine (K)-specific methyltransferase 2E.
    
 0.891
plod2
Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform.
     
  0.878
B8JJX1_DANRE
Si:ch73-54n14.2.
     
 0.877
camkmt
Calmodulin-lysine N-methyltransferase.
     
 0.877
smyd3
SET and MYND domain-containing 3.
    
 0.874
suv39h1a
Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...]
    
 0.873
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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