Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
gata5Transcription factor gata5. (383 aa)    
Predicted Functional Partners:
nkx2.5
NK2 homeobox 5.
   
 
 0.923
sox32
SRY-box transcription factor 32.
   
 
 0.880
nfatc1
Nuclear factor of-activated T cells 1.
    
 0.838
zfpm2a
Zinc finger protein, FOG family member 2a.
    
 0.835
hand2
Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis.
   
 
 0.825
tbx5a
T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters.
   
 0.816
mixl1
Mix paired-like homeobox.
      
 0.811
tbx20
T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
   
 
 0.800
nkx2.7
NK2 transcription factor-related 7.
   
 
 0.785
srfa
Serum response factor a.
    
 0.780
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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