STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zgc:113278Translocating chain-associated membrane protein; Belongs to the TRAM family. (374 aa)    
Predicted Functional Partners:
ccdc47
Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway (By similarity).
    
 
 0.952
tram1
Translocating chain-associated membrane protein; Belongs to the TRAM family.
  
  
 
0.901
sec63
SEC63 homolog, protein translocation regulator.
   
 
 0.678
h6pd
Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).
      
 0.670
tmem208
Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy; Belongs to the TMEM208 family.
      
 0.655
tmco1
Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (By similarity); Belongs to the TMCO1 family.
   
  
 0.617
scp2a
Sterol carrier protein 2a; Belongs to the thiolase-like superfamily. Thiolase family.
      
 0.568
hm13
Histocompatibility (minor) 13.
   
 
 0.541
gnmt
Glycine N-methyltransferase.
      
 0.540
emc6
ER membrane protein complex subunit 6; Belongs to the EMC6 family.
      
 0.540
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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