node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
crx | isl1 | ENSDARP00000030526 | ENSDARP00000012903 | Cone-rod homeobox. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.500 |
crx | neurod1 | ENSDARP00000030526 | ENSDARP00000026490 | Cone-rod homeobox. | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. | 0.839 |
crx | nr2e3 | ENSDARP00000030526 | ENSDARP00000111061 | Cone-rod homeobox. | Nuclear receptor subfamily 2, group E, member 3. | 0.947 |
elavl3 | her12 | ENSDARP00000030680 | ENSDARP00000044079 | ELAV-like protein; Belongs to the RRM elav family. | BHLH transcription factor. | 0.500 |
elavl3 | isl1 | ENSDARP00000030680 | ENSDARP00000012903 | ELAV-like protein; Belongs to the RRM elav family. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.768 |
elavl3 | neurod1 | ENSDARP00000030680 | ENSDARP00000026490 | ELAV-like protein; Belongs to the RRM elav family. | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. | 0.852 |
elavl3 | nkx2.2a | ENSDARP00000030680 | ENSDARP00000153588 | ELAV-like protein; Belongs to the RRM elav family. | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | 0.569 |
elavl3 | pax6a | ENSDARP00000030680 | ENSDARP00000135767 | ELAV-like protein; Belongs to the RRM elav family. | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. | 0.713 |
elavl3 | sox2 | ENSDARP00000030680 | ENSDARP00000095266 | ELAV-like protein; Belongs to the RRM elav family. | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). | 0.786 |
her12 | elavl3 | ENSDARP00000044079 | ENSDARP00000030680 | BHLH transcription factor. | ELAV-like protein; Belongs to the RRM elav family. | 0.500 |
her12 | isl1 | ENSDARP00000044079 | ENSDARP00000012903 | BHLH transcription factor. | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | 0.514 |
her12 | neurod1 | ENSDARP00000044079 | ENSDARP00000026490 | BHLH transcription factor. | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. | 0.815 |
her12 | nkx2.2a | ENSDARP00000044079 | ENSDARP00000153588 | BHLH transcription factor. | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | 0.504 |
her12 | nkx6.1 | ENSDARP00000044079 | ENSDARP00000035373 | BHLH transcription factor. | NK6 homeobox 1. | 0.456 |
her12 | pax4 | ENSDARP00000044079 | ENSDARP00000013792 | BHLH transcription factor. | Paired box 4. | 0.440 |
her12 | pax6a | ENSDARP00000044079 | ENSDARP00000135767 | BHLH transcription factor. | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. | 0.588 |
her12 | sox2 | ENSDARP00000044079 | ENSDARP00000095266 | BHLH transcription factor. | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). | 0.474 |
isl1 | crx | ENSDARP00000012903 | ENSDARP00000030526 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | Cone-rod homeobox. | 0.500 |
isl1 | elavl3 | ENSDARP00000012903 | ENSDARP00000030680 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | ELAV-like protein; Belongs to the RRM elav family. | 0.768 |
isl1 | her12 | ENSDARP00000012903 | ENSDARP00000044079 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). | BHLH transcription factor. | 0.514 |