Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)    
Predicted Functional Partners:
slc25a21
Solute carrier family 25 member 21; Belongs to the mitochondrial carrier (TC 2.A.29) family.
    
   0.967
phf13
PHD finger protein 13.
    
   0.967
nkx2.5
NK2 homeobox 5.
   
 
 0.965
gata4
GATA-binding protein 4.
   
 
 0.940
blvra
Biliverdin reductase A.
    
   0.935
hand2
Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis.
   
  
 0.887
gsc
Homeobox protein goosecoid.
    
   0.876
gata6
GATA-binding protein 6.
   
 
 0.831
isl1
Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity).
   
 
 0.812
gata5
Transcription factor gata5.
   
 
 0.800
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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