STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mettl13eEF1A lysine and N-terminal methyltransferase; Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (eef1a1 and eef1a2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates the N-terminus of eef1a1 and eef1a2. Via its N-terminus dimethylates lysine residues of eef1a1 and eef1a2. (690 aa)    
Predicted Functional Partners:
eef1akmt2
EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
      
 0.896
mettl14
N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.
      
 0.854
atpsckmt
FATP synthase c subunit lysine N-methyltransferase.
   
  
 0.836
plpp6
Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP). PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation (By similarity).
      
 0.823
eef2kmt
Eukaryotic elongation factor 2 lysine methyltransferase.
      
 0.816
etfbkmt
Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain. Belongs to the methyltransferase superfamily. ETFBKMT family.
      
 0.815
mettl21a
Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase; Belongs to the methyltransferase superfamily. METTL21 family.
      
 0.776
pigc
Phosphatidylinositol glycan anchor biosynthesis, class C.
      
 0.772
METTL18
Si:dkey-15f17.8.
      
 0.748
prrc2c
Proline-rich coiled-coil 2C.
      
 0.748
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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