node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aida | axin1 | ENSDARP00000026849 | ENSDARP00000135613 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | 0.563 |
aida | ehbp1 | ENSDARP00000026849 | ENSDARP00000127979 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | EH domain-binding protein 1. | 0.720 |
aida | mia3 | ENSDARP00000026849 | ENSDARP00000060504 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | MIA SH3 domain ER export factor 3. | 0.473 |
aida | nfkbiaa | ENSDARP00000026849 | ENSDARP00000109941 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. | 0.518 |
aida | nfkbiab | ENSDARP00000026849 | ENSDARP00000015303 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | 0.444 |
axin1 | aida | ENSDARP00000135613 | ENSDARP00000026849 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | 0.563 |
ehbp1 | aida | ENSDARP00000127979 | ENSDARP00000026849 | EH domain-binding protein 1. | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | 0.720 |
mia3 | aida | ENSDARP00000060504 | ENSDARP00000026849 | MIA SH3 domain ER export factor 3. | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | 0.473 |
nfkbiaa | aida | ENSDARP00000109941 | ENSDARP00000026849 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | 0.518 |
nfkbiaa | nfkbiab | ENSDARP00000109941 | ENSDARP00000015303 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | 0.912 |
nfkbiab | aida | ENSDARP00000015303 | ENSDARP00000026849 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. | 0.444 |
nfkbiab | nfkbiaa | ENSDARP00000015303 | ENSDARP00000109941 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. | 0.912 |