| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSDARP00000132681 | hdac1 | ENSDARP00000132681 | ENSDARP00000051798 | Amine oxidase. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.577 |
| ENSDARP00000132681 | hdac3 | ENSDARP00000132681 | ENSDARP00000054625 | Amine oxidase. | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). | 0.538 |
| ENSDARP00000132681 | hdac8 | ENSDARP00000132681 | ENSDARP00000017858 | Amine oxidase. | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.538 |
| ENSDARP00000132681 | kdm1a | ENSDARP00000132681 | ENSDARP00000080193 | Amine oxidase. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.449 |
| ENSDARP00000132681 | mao | ENSDARP00000132681 | ENSDARP00000032834 | Amine oxidase. | Amine oxidase [flavin-containing]; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta- phenylethylamine (PEA); Belongs to the flavin monoamine oxidase family. | 0.909 |
| ENSDARP00000132681 | rcor2 | ENSDARP00000132681 | ENSDARP00000026854 | Amine oxidase. | REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. | 0.638 |
| chd4a | chd4b | ENSDARP00000111640 | ENSDARP00000152065 | Chromodomain helicase DNA-binding protein 4a. | Chromodomain helicase DNA-binding protein 4b. | 0.577 |
| chd4a | hdac1 | ENSDARP00000111640 | ENSDARP00000051798 | Chromodomain helicase DNA-binding protein 4a. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.737 |
| chd4a | hdac3 | ENSDARP00000111640 | ENSDARP00000054625 | Chromodomain helicase DNA-binding protein 4a. | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). | 0.578 |
| chd4a | hdac8 | ENSDARP00000111640 | ENSDARP00000017858 | Chromodomain helicase DNA-binding protein 4a. | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.578 |
| chd4a | kdm1a | ENSDARP00000111640 | ENSDARP00000080193 | Chromodomain helicase DNA-binding protein 4a. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.457 |
| chd4a | rcor2 | ENSDARP00000111640 | ENSDARP00000026854 | Chromodomain helicase DNA-binding protein 4a. | REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. | 0.742 |
| chd4b | chd4a | ENSDARP00000152065 | ENSDARP00000111640 | Chromodomain helicase DNA-binding protein 4b. | Chromodomain helicase DNA-binding protein 4a. | 0.577 |
| chd4b | hdac1 | ENSDARP00000152065 | ENSDARP00000051798 | Chromodomain helicase DNA-binding protein 4b. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.825 |
| chd4b | hdac3 | ENSDARP00000152065 | ENSDARP00000054625 | Chromodomain helicase DNA-binding protein 4b. | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). | 0.578 |
| chd4b | hdac8 | ENSDARP00000152065 | ENSDARP00000017858 | Chromodomain helicase DNA-binding protein 4b. | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). | 0.578 |
| chd4b | kdm1a | ENSDARP00000152065 | ENSDARP00000080193 | Chromodomain helicase DNA-binding protein 4b. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.716 |
| chd4b | rcor2 | ENSDARP00000152065 | ENSDARP00000026854 | Chromodomain helicase DNA-binding protein 4b. | REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family. | 0.750 |
| hdac1 | ENSDARP00000132681 | ENSDARP00000051798 | ENSDARP00000132681 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Amine oxidase. | 0.577 |
| hdac1 | chd4a | ENSDARP00000051798 | ENSDARP00000111640 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Chromodomain helicase DNA-binding protein 4a. | 0.737 |