STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nplN-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). (307 aa)    
Predicted Functional Partners:
nansa
N-acetylneuraminic acid synthase a.
    
 0.956
gne
Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.
    
 0.927
renbp
Renin-binding protein.
   
 
  0.909
ppp1r8a
Protein phosphatase 1, regulatory subunit 8a.
      
 0.807
enosf1
Enolase superfamily member 1.
 
 
  
 0.725
st3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.
      
 0.669
neu4
Neu4 protein.
   
 
 0.604
gclc
Glutamate-cysteine ligase, catalytic subunit.
   
 0.597
fuom
Fucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses; Belongs to the RbsD / FucU family.
  
  
 0.591
btg3
B-cell translocation gene 3.
      
 0.576
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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