| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aldh1a3 | cyp26a1 | ENSDARP00000055592 | ENSDARP00000041727 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.984 |
| aldh1a3 | cyp26b1 | ENSDARP00000055592 | ENSDARP00000101543 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | 0.974 |
| aldh1a3 | dhrs3a | ENSDARP00000055592 | ENSDARP00000066124 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase/reductase (SDR family) member 3a. | 0.922 |
| aldh1a3 | dhrs4 | ENSDARP00000055592 | ENSDARP00000106922 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase/reductase (SDR family) member 4. | 0.892 |
| aldh1a3 | dhrs9 | ENSDARP00000055592 | ENSDARP00000027139 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.830 |
| aldh1a3 | rdh10a | ENSDARP00000055592 | ENSDARP00000066702 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Retinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.922 |
| aldh1a3 | rdh10b | ENSDARP00000055592 | ENSDARP00000011528 | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | Retinol dehydrogenase 10-B; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.980 |
| cyp26a1 | aldh1a3 | ENSDARP00000041727 | ENSDARP00000055592 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | 0.984 |
| cyp26a1 | cyp26b1 | ENSDARP00000041727 | ENSDARP00000101543 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | 0.956 |
| cyp26a1 | dgat1a | ENSDARP00000041727 | ENSDARP00000137795 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | O-acyltransferase. | 0.961 |
| cyp26a1 | dhrs3a | ENSDARP00000041727 | ENSDARP00000066124 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Dehydrogenase/reductase (SDR family) member 3a. | 0.990 |
| cyp26a1 | dhrs4 | ENSDARP00000041727 | ENSDARP00000106922 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Dehydrogenase/reductase (SDR family) member 4. | 0.948 |
| cyp26a1 | dhrs9 | ENSDARP00000041727 | ENSDARP00000027139 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.892 |
| cyp26a1 | lrata | ENSDARP00000041727 | ENSDARP00000054227 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Lecithin retinol acyltransferase a. | 0.965 |
| cyp26a1 | lratb.2 | ENSDARP00000041727 | ENSDARP00000126676 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Lecithin retinol acyltransferase b, tandem duplicate 2. | 0.970 |
| cyp26a1 | rdh10a | ENSDARP00000041727 | ENSDARP00000066702 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Retinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.985 |
| cyp26a1 | rdh10b | ENSDARP00000041727 | ENSDARP00000011528 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | Retinol dehydrogenase 10-B; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.994 |
| cyp26b1 | aldh1a3 | ENSDARP00000101543 | ENSDARP00000055592 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | Retinaldehyde dehydrogenase family 1 subfamily A3; Belongs to the aldehyde dehydrogenase family. | 0.974 |
| cyp26b1 | cyp26a1 | ENSDARP00000101543 | ENSDARP00000041727 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] | 0.956 |
| cyp26b1 | dgat1a | ENSDARP00000101543 | ENSDARP00000137795 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. | O-acyltransferase. | 0.781 |
