Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
slc9a8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (640 aa)    
Predicted Functional Partners:
ttc37
Tetratricopeptide repeat domain 37.
      
 0.739
tmem254
Transmembrane protein 254.
     
 0.713
dusp28
Dual-specificity phosphatase 28.
      
 0.704
xrra1
X-ray radiation resistance-associated 1.
      
 0.698
apooa
MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
      
 0.696
B8JLK9_DANRE
Si:dkey-69o16.5.
      
 0.688
zc3h15
Zinc finger CCCH domain-containing protein 15; Protects drg1 from proteolytic degradation.
   
  
 0.645
wdr33
WD repeat domain 33.
      
 0.626
slc26a11
Solute carrier family 26 member 11.
     
 0.617
rack1
Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
    
 
 0.604
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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