Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
idh2Isocitrate dehydrogenase (NADP(+)) 2. (225 aa)    
Predicted Functional Partners:
idh3a
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.997
aco2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.996
cs
Citrate synthase, mitochondrial.
  
 0.988
idh3b
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.980
idh3g
Isocitrate dehydrogenase [NAD] subunit, mitochondrial.
  
 0.979
idh1
Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 0.972
aco1
Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family.
  
 0.972
ireb2
Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family.
  
 0.963
ogdha
Oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide).
   
 0.962
sdha
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 0.958
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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