Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sec62SEC62 homolog, preprotein translocation factor. (394 aa)    
Predicted Functional Partners:
sec63
SEC63 homolog, protein translocation regulator.
   
 0.999
sec61b
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
   
 
 0.970
sec61g
SEC61 translocon gamma subunit.
   
 
 0.958
Ccpg1
Uncharacterized protein.
   
 
 0.956
ccpg1
Cell cycle progression 1.
   
 
 0.956
spcs2
Probable signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
   
 
 0.937
spcs1
Signal peptidase complex subunit 1 homolog (S. cerevisiae).
   
 
 0.933
sec61a1
Protein transport protein Sec61 subunit alpha-like 1; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adapter proteins (By similarity). Plays a role in the pronephric kidney tubule development.
   
 
 0.889
sec61a1l
Protein transport protein Sec61 subunit alpha-like 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity).
   
 
 0.889
snrnp200
Small nuclear ribonucleoprotein 200 (U5).
     
 0.873
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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