Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
atf3Activating transcription factor 3. (202 aa)    
Predicted Functional Partners:
jun
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.997
june
JunE proto-oncogene, AP-1 transcription factor subunit.
   
 0.984
ddit3
DNA-damage-inducible transcript 3.
   
 
 0.983
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
   
 
 0.976
mdm2
E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
   
 
 0.975
atf4a
Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity).
   
 0.964
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b.
   
 0.956
junba
JunB proto-oncogene, AP-1 transcription factor subunit a.
   
 0.950
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma.
   
 
 0.932
jund
JunD proto-oncogene, AP-1 transcription factor subunit.
   
 0.922
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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