STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmbx1aDiencephalon/mesencephalon homeobox protein 1-A; Required for eye and tectum development. May act as a transcriptional repressor. (383 aa)    
Predicted Functional Partners:
otx2b
Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.
   
 
0.634
plpp1a
Phospholipid phosphatase 1a.
      
 0.567
rs1a
Retinoschisis (X-linked, juvenile) 1.
   
  
 0.485
themis2
Thymocyte selection-associated family member 2.
      
 0.484
irx1b
Iroquois homeobox protein 1, b.
   
 
 0.483
six3a
Sine oculis homeobox homolog 3a.
   
  
 0.469
bahd1
Bromo adjacent homology domain-containing 1.
      
 0.463
pax2a
Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.
   
 
 0.461
irx4a
Iroquois homeobox protein 4a.
   
 
 0.457
mab21l2
Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family.
   
 
 0.444
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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