ikbkg protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ikbkg

Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)

Predicted Functional Partners:

chuk

0.998

ikbkb

0.997

tab2

0.994

tab3

0.992

traf6

0.987

ripk1l

0.986

tbk1

0.982

tank

0.979

ikbke

0.978

map3k7

0.976

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
chuk	ikbkb	ENSDARP00000013115	ENSDARP00000117685	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.994
chuk	ikbkg	ENSDARP00000013115	ENSDARP00000027612	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.998
chuk	map3k7	ENSDARP00000013115	ENSDARP00000006286	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Mitogen-activated protein kinase kinase kinase 7.	0.978
chuk	ripk1l	ENSDARP00000013115	ENSDARP00000014604	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Receptor (TNFRSF)-interacting serine-threonine kinase 1,-like.	0.994
chuk	tab2	ENSDARP00000013115	ENSDARP00000019647	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development.	0.993
chuk	tab3	ENSDARP00000013115	ENSDARP00000083707	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like.	0.990
chuk	tank	ENSDARP00000013115	ENSDARP00000134987	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TRAF family member-associated NFKB activator.	0.792
chuk	tbk1	ENSDARP00000013115	ENSDARP00000132718	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TANK-binding kinase 1.	0.494
chuk	traf6	ENSDARP00000013115	ENSDARP00000036715	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.998
ikbkb	chuk	ENSDARP00000117685	ENSDARP00000013115	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.994
ikbkb	ikbke	ENSDARP00000117685	ENSDARP00000074566	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.538
ikbkb	ikbkg	ENSDARP00000117685	ENSDARP00000027612	Inhibitor of nuclear factor kappa B kinase subunit beta.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.997
ikbkb	map3k7	ENSDARP00000117685	ENSDARP00000006286	Inhibitor of nuclear factor kappa B kinase subunit beta.	Mitogen-activated protein kinase kinase kinase 7.	0.995
ikbkb	ripk1l	ENSDARP00000117685	ENSDARP00000014604	Inhibitor of nuclear factor kappa B kinase subunit beta.	Receptor (TNFRSF)-interacting serine-threonine kinase 1,-like.	0.993
ikbkb	tab2	ENSDARP00000117685	ENSDARP00000019647	Inhibitor of nuclear factor kappa B kinase subunit beta.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development.	0.983
ikbkb	tab3	ENSDARP00000117685	ENSDARP00000083707	Inhibitor of nuclear factor kappa B kinase subunit beta.	Mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like.	0.985
ikbkb	tank	ENSDARP00000117685	ENSDARP00000134987	Inhibitor of nuclear factor kappa B kinase subunit beta.	TRAF family member-associated NFKB activator.	0.775
ikbkb	tbk1	ENSDARP00000117685	ENSDARP00000132718	Inhibitor of nuclear factor kappa B kinase subunit beta.	TANK-binding kinase 1.	0.473
ikbkb	traf6	ENSDARP00000117685	ENSDARP00000036715	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.998
ikbke	ikbkb	ENSDARP00000074566	ENSDARP00000117685	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.538

page 1 of 6

Server load: low (8%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About