STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pth3rParathyroid hormone 1 receptor b; Belongs to the G-protein coupled receptor 2 family. (542 aa)    
Predicted Functional Partners:
pth1a
Parathyroid hormone 1a.
   
 0.994
pth2
Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of pth2r resulting in adenyl cyclase activation and intracellular calcium level elevation; Belongs to the parathyroid hormone family.
   
 0.993
pth1b
Parathyroid hormone ligand type-2.
     
 0.985
pthlhb
Parathyroid hormone-related peptide 2.
    
 
 0.936
pthlha
Parathyroid hormone-like hormone a.
    
 
 0.895
pip5k1bb
Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b.
      
 0.811
pip5k1cb
Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b.
      
 0.811
pip5k1ab
Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b.
      
 0.660
pth4
Parathyroid hormone 4; Neuroendocrine peptide which is produced by a subset of neurons in the hypothalamus. Activates the G-protein coupled receptors pth1ra, pth1rb and pth2r with similar affinity. Receptor binding stimulates intracellular cAMP production. Plays a role in bone mineralization by regulating expression of factors involved in phosphate homeostasis. Important for embryonic bone development.
      
 0.645
taco1
Translational activator of mitochondrially encoded cytochrome c oxidase I.
      
 0.569
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.