Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
eif2s3Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In o [...] (472 aa)    
Predicted Functional Partners:
eif2s2
Eukaryotic translation initiation factor 2, subunit 2 beta.
   
 0.999
eif5
Eukaryotic translation initiation factor 5.
   
 0.996
eif2s1b
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
   
 0.996
eif2s1a
Eukaryotic translation initiation factor 2, subunit 1 alpha, like.
   
 0.994
eif5b
Eukaryotic translation initiation factor 5B.
  
 
 0.993
rps23
Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family.
   
 0.990
abce1
ATP-binding cassette, sub-family E (OABP), member 1.
   
 
 0.989
eif2b5
Eukaryotic translation initiation factor 2B, subunit 5 epsilon.
   
 0.988
rps13
Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family.
  
 0.986
rack1
Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
   
 
 0.985
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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