Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
brwd3Bromodomain and WD repeat domain-containing 3. (1624 aa)    
Predicted Functional Partners:
ddb1
Damage-specific DNA-binding protein 1.
    
 
 0.793
sh3bgrl
SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family.
      
 0.773
hdx
Highly divergent homeobox.
   
  
 0.726
akap8l
A kinase (PRKA) anchor protein 8-like; Belongs to the AKAP95 family.
    
 
 0.694
ubxn7
UBX domain protein 7.
   
 
 0.691
apool
MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
   
  
 0.667
kif7
Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics.
   
 0.649
ofd1
Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis; Belongs to the OFD1 family.
    
 
 0.634
atrx
ATRX chromatin remodeler.
  
 
 0.626
xpnpep3
X-prolyl aminopeptidase (Aminopeptidase P) 3, putative.
     
 0.621
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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