STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pou3f1POU domain, class 3, transcription factor 1; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal; Belongs to the POU transcription factor family. Class-3 subfamily. (368 aa)    
Predicted Functional Partners:
egr2b
Early growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
   
 
 0.751
fam168a
Family with sequence similarity 168 member A.
      
 0.670
sox10
HMG-box transcription factor Sox10.
   
 
 0.665
fam168b
Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Belongs to the FAM168 family.
      
 0.661
sox2
Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
   
 
 0.585
egr2a
Early growth response 2a.
    
 
 0.579
olig2
Oligodendrocyte lineage transcription factor 2.
  
  
 0.572
otx2b
Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain.
   
 
 0.504
six2a
Sine oculis homeobox homolog 2.1.
   
  
 0.481
mpz
Myelin protein zero.
   
  
 0.461
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.