bcl2l1 protein (Danio rerio) - STRING interaction network

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Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
apaf1	badb	ENSDARP00000008347	ENSDARP00000071687	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	BCL2-associated agonist of cell death b.	0.444
apaf1	bcl2l1	ENSDARP00000008347	ENSDARP00000027919	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Bcl-XL-like protein 1.	0.987
apaf1	bcl2l11	ENSDARP00000008347	ENSDARP00000097551	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	BCL2-like 11.	0.780
apaf1	becn1	ENSDARP00000008347	ENSDARP00000100986	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...]	0.503
apaf1	casp9	ENSDARP00000008347	ENSDARP00000047019	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.999
apaf1	cycsb	ENSDARP00000008347	ENSDARP00000034555	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.999
apaf1	tp53	ENSDARP00000008347	ENSDARP00000116736	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.855
apaf1	zgc:153993	ENSDARP00000008347	ENSDARP00000139602	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	Zgc:153993 protein.	0.747
badb	apaf1	ENSDARP00000071687	ENSDARP00000008347	BCL2-associated agonist of cell death b.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	0.444
badb	bcl2l1	ENSDARP00000071687	ENSDARP00000027919	BCL2-associated agonist of cell death b.	Bcl-XL-like protein 1.	0.999
badb	bcl2l11	ENSDARP00000071687	ENSDARP00000097551	BCL2-associated agonist of cell death b.	BCL2-like 11.	0.884
badb	casp9	ENSDARP00000071687	ENSDARP00000047019	BCL2-associated agonist of cell death b.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.503
badb	cycsb	ENSDARP00000071687	ENSDARP00000034555	BCL2-associated agonist of cell death b.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.566
badb	tp53	ENSDARP00000071687	ENSDARP00000116736	BCL2-associated agonist of cell death b.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.610
badb	zgc:153993	ENSDARP00000071687	ENSDARP00000139602	BCL2-associated agonist of cell death b.	Zgc:153993 protein.	0.636
bcl2l1	apaf1	ENSDARP00000027919	ENSDARP00000008347	Bcl-XL-like protein 1.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).	0.987
bcl2l1	badb	ENSDARP00000027919	ENSDARP00000071687	Bcl-XL-like protein 1.	BCL2-associated agonist of cell death b.	0.999
bcl2l1	bcl2l11	ENSDARP00000027919	ENSDARP00000097551	Bcl-XL-like protein 1.	BCL2-like 11.	0.999
bcl2l1	becn1	ENSDARP00000027919	ENSDARP00000100986	Bcl-XL-like protein 1.	Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...]	0.998
bcl2l1	casp9	ENSDARP00000027919	ENSDARP00000047019	Bcl-XL-like protein 1.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.997

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