appbp2 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

appbp2

Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2. (586 aa)

Predicted Functional Partners:

cul2

0.993

fem1c

0.963

cops3

0.939

cops2

0.934

arih1

0.914

zswim5

0.913

zyg11

0.913

zer1

0.912

zswim6

0.900

ENSDARP00000134209

0.900

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSDARP00000134209	appbp2	ENSDARP00000134209	ENSDARP00000027941	Si:ch1073-82l19.1.	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	0.900
ENSDARP00000134209	arih1	ENSDARP00000134209	ENSDARP00000006476	Si:ch1073-82l19.1.	E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...]	0.901
ENSDARP00000134209	cul2	ENSDARP00000134209	ENSDARP00000123380	Si:ch1073-82l19.1.	Cullin 2; Belongs to the cullin family.	0.981
ENSDARP00000134209	fem1c	ENSDARP00000134209	ENSDARP00000140150	Si:ch1073-82l19.1.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.903
ENSDARP00000134209	zer1	ENSDARP00000134209	ENSDARP00000131818	Si:ch1073-82l19.1.	Zyg-11-related, cell cycle regulator.	0.900
ENSDARP00000134209	zswim5	ENSDARP00000134209	ENSDARP00000072767	Si:ch1073-82l19.1.	Zinc finger, SWIM-type-containing 5.	0.900
ENSDARP00000134209	zswim6	ENSDARP00000134209	ENSDARP00000133495	Si:ch1073-82l19.1.	Zinc finger, SWIM-type-containing 6.	0.900
ENSDARP00000134209	zyg11	ENSDARP00000134209	ENSDARP00000094887	Si:ch1073-82l19.1.	Protein zyg-11 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.	0.902
appbp2	ENSDARP00000134209	ENSDARP00000027941	ENSDARP00000134209	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Si:ch1073-82l19.1.	0.900
appbp2	arih1	ENSDARP00000027941	ENSDARP00000006476	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...]	0.914
appbp2	cops2	ENSDARP00000027941	ENSDARP00000012359	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.	0.934
appbp2	cops3	ENSDARP00000027941	ENSDARP00000021983	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).	0.939
appbp2	cul2	ENSDARP00000027941	ENSDARP00000123380	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Cullin 2; Belongs to the cullin family.	0.993
appbp2	fem1c	ENSDARP00000027941	ENSDARP00000140150	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.	0.963
appbp2	zer1	ENSDARP00000027941	ENSDARP00000131818	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Zyg-11-related, cell cycle regulator.	0.912
appbp2	zswim5	ENSDARP00000027941	ENSDARP00000072767	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Zinc finger, SWIM-type-containing 5.	0.913
appbp2	zswim6	ENSDARP00000027941	ENSDARP00000133495	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Zinc finger, SWIM-type-containing 6.	0.900
appbp2	zyg11	ENSDARP00000027941	ENSDARP00000094887	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	Protein zyg-11 homolog; Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC. Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.	0.913
arih1	ENSDARP00000134209	ENSDARP00000006476	ENSDARP00000134209	E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...]	Si:ch1073-82l19.1.	0.901
arih1	appbp2	ENSDARP00000006476	ENSDARP00000027941	E3 ubiquitin-protein ligase arih1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 ube2l3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated. E3 ubiquitin- protein ligase activity is activated upon binding to neddylated cullin- RING ubiquitin ligase com [...]	Amyloid beta precursor protein (cytoplasmic tail)-binding protein 2.	0.914

page 1 of 5

Server load: low (12%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About