STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (913 aa)    
Predicted Functional Partners:
grb2b
Growth factor receptor-bound protein 2b.
   
 0.986
egfra
Epidermal growth factor receptor precursor.
   
 0.967
spry2
Sprouty RTK-signaling antagonist 2.
    
 0.962
met
MET proto-oncogene, receptor tyrosine kinase.
   
 0.941
rapgef1b
Rap guanine nucleotide exchange factor (GEF) 1b.
   
 0.934
rapgef1a
Rap guanine nucleotide exchange factor (GEF) 1a.
    
 0.933
sh3kbp1
SH3-domain kinase-binding protein 1.
    
 0.927
insra
Tyrosine-protein kinase receptor.
    
 0.923
insrb
Tyrosine-protein kinase receptor.
   
 0.923
tgfbr2b
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
    
 0.916
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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