Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
vangl1Vang-like protein. (527 aa)    
Predicted Functional Partners:
prickle1a
Prickle homolog 1a.
    
 0.998
prickle2b
Prickle homolog 2b.
   
 0.998
prickle2a
Prickle homolog 2a.
    
 0.997
dvl2
Dishevelled segment polarity protein 2.
    
 0.996
prickle1b
Prickle homolog 1b.
    
 0.996
dvl3a
Dishevelled segment polarity protein 3a.
    
 0.990
dvl3
Dishevelled segment polarity protein 3b.
    
 0.990
prickle3
Prickle homolog 3.
    
 0.985
dvl1b
Dishevelled segment polarity protein 1b.
    
 0.984
vangl2
Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...]
  
  
0.966
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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