Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppp1r13baProtein phosphatase 1, regulatory subunit 13Ba. (1110 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.
    
 0.911
ppp1cb
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
 0.799
ppp1cbl
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
 0.799
ppp1caa
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
  0.748
ppp1cab
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
  0.748
ppp1cc
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
  0.748
il10
Interleukin-10.
    
  0.719
LOC101882195
Uncharacterized protein.
      
 0.719
nbl1
Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family.
      
 0.688
trpc6b
Transient receptor potential cation channel, subfamily C, member 6b.
      
 0.682
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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