STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spi1bSI:bY184L24.2.1 (Transcription factor spi1). (296 aa)    
Predicted Functional Partners:
gata1a
GATA-binding protein 1a.
   
 
 0.979
irf8
Interferon regulatory factor 8.
   
 
 0.962
runx1
Runt-related transcription factor.
   
 
 0.955
lcp1
Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells (By similarity).
   
  
 0.927
gata2a
GATA-binding protein 2a.
    
 
 0.921
csf1ra
Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...]
   
  
 0.899
myb
V-myb avian myeloblastosis viral oncogene homolog.
   
  
 0.897
mpeg1.1
Macrophage-expressed 1, tandem duplicate 1.
   
  
 0.889
csf3r
Colony-stimulating factor 3 receptor (granulocyte).
   
 
 0.879
lmo2
Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells.
   
  
 0.874
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.