Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
prf1.1Perforin 1.1. (580 aa)    
Predicted Functional Partners:
nkl.1
NK-lysin tandem duplicate 2.
   
  
 0.903
cd8a
CD8 antigen, alpha polypeptide.
   
  
 0.864
il2rb
Interleukin 2 receptor, beta.
   
  
 0.864
cd247l
CD247 antigen-like.
   
  
 0.849
faslg
Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family.
   
 0.754
nkl.4
NK-lysin tandem duplicate 4.
   
  
 0.747
ccl38.6
C-C motif chemokine.
   
 0.730
lcp2b
Lymphocyte cytosolic protein 2b.
      
 0.720
nkl.3
NK-lysin tandem duplicate 3.
   
  
 0.707
tnfsf14
TNF superfamily member 14; Belongs to the tumor necrosis factor family.
      
 0.683
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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