Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nsmce4aNon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (346 aa)    
Predicted Functional Partners:
nsmce1
Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. Belongs to the NSE1 family.
   
 0.999
ndnl2
Necdin-like 2.
   
 0.998
nsmce2
NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase.
    
 0.998
A5PN27_DANRE
Si:dkey-119f1.1.
   
 0.988
smc5
Structural maintenance of chromosomes 5.
   
 
 0.983
smc6
Structural maintenance of chromosomes 6.
   
 
 0.894
smc3
Structural maintenance of chromosomes protein.
   
 0.820
slf1
SMC5-SMC6 complex localization factor 1.
    
 
 0.784
brca2
BRCA2 DNA repair-associated.
    
 
 0.731
zbtb2b
Zinc finger and BTB domain-containing 2b.
    
 
 0.711
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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