node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000136668 | aph1b | ENSDARP00000136668 | ENSDARP00000011743 | Ncstrn_small domain-containing protein. | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | 0.962 |
ENSDARP00000136668 | appa | ENSDARP00000136668 | ENSDARP00000130555 | Ncstrn_small domain-containing protein. | Amyloid beta (A4) precursor protein a. | 0.879 |
ENSDARP00000136668 | notch1a | ENSDARP00000136668 | ENSDARP00000137942 | Ncstrn_small domain-containing protein. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.770 |
ENSDARP00000136668 | psen1 | ENSDARP00000136668 | ENSDARP00000136264 | Ncstrn_small domain-containing protein. | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. | 0.958 |
ENSDARP00000136668 | psen2 | ENSDARP00000136668 | ENSDARP00000011791 | Ncstrn_small domain-containing protein. | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. | 0.965 |
ENSDARP00000136668 | psenen | ENSDARP00000136668 | ENSDARP00000090230 | Ncstrn_small domain-containing protein. | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. | 0.993 |
ENSDARP00000136668 | zgc:114200 | ENSDARP00000136668 | ENSDARP00000133858 | Ncstrn_small domain-containing protein. | Zgc:114200. | 0.962 |
aph1b | ENSDARP00000136668 | ENSDARP00000011743 | ENSDARP00000136668 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Ncstrn_small domain-containing protein. | 0.962 |
aph1b | appa | ENSDARP00000011743 | ENSDARP00000130555 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Amyloid beta (A4) precursor protein a. | 0.639 |
aph1b | notch1a | ENSDARP00000011743 | ENSDARP00000137942 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.864 |
aph1b | psen1 | ENSDARP00000011743 | ENSDARP00000136264 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. | 0.985 |
aph1b | psen2 | ENSDARP00000011743 | ENSDARP00000011791 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. | 0.986 |
aph1b | psenen | ENSDARP00000011743 | ENSDARP00000090230 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. | 0.999 |
aph1b | zgc:114200 | ENSDARP00000011743 | ENSDARP00000133858 | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | Zgc:114200. | 0.902 |
appa | ENSDARP00000136668 | ENSDARP00000130555 | ENSDARP00000136668 | Amyloid beta (A4) precursor protein a. | Ncstrn_small domain-containing protein. | 0.879 |
appa | aph1b | ENSDARP00000130555 | ENSDARP00000011743 | Amyloid beta (A4) precursor protein a. | Gamma-secretase subunit Aph-1b; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). | 0.639 |
appa | ctnnb1 | ENSDARP00000130555 | ENSDARP00000139205 | Amyloid beta (A4) precursor protein a. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.449 |
appa | notch1a | ENSDARP00000130555 | ENSDARP00000137942 | Amyloid beta (A4) precursor protein a. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.430 |
appa | psen1 | ENSDARP00000130555 | ENSDARP00000136264 | Amyloid beta (A4) precursor protein a. | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. | 0.953 |
appa | psen2 | ENSDARP00000130555 | ENSDARP00000011791 | Amyloid beta (A4) precursor protein a. | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. | 0.894 |