Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sem1SEM1 26S proteasome complex subunit. (92 aa)    
Predicted Functional Partners:
brca2
BRCA2 DNA repair-associated.
    
 0.996
psmd6
Proteasome 26S subunit, non-ATPase 6.
   
 0.994
psmd7
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog).
   
 0.989
psmd3
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3.
   
 0.988
psmc5
Proteasome (Prosome, macropain) 26S subunit, ATPase, 5; Belongs to the AAA ATPase family.
   
 0.978
psmc6
Proteasome (Prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family.
   
 0.974
psmd14
Proteasome 26S subunit, non-ATPase 14.
   
 0.973
psmd8
Proteasome 26S subunit, non-ATPase 8.
   
 0.969
adrm1
Proteasomal ubiquitin receptor ADRM1; Functions as a proteasomal ubiquitin receptor. Promotes the deubiquitinating activity associated with the 26S proteasome (By similarity); Belongs to the ADRM1 family.
   
 0.969
psmd1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
    
 0.968
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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