Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
ccdc174Coiled-coil domain-containing 174. (460 aa)    
Predicted Functional Partners:
eif4a3
Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...]
    
 
 0.947
tatdn2
TatD DNase domain-containing 2.
 
 
  
 0.925
nrde2
NRDE-2, necessary for RNA interference, domain-containing.
    
 
 0.875
alpk3b
Alpha-kinase 3b.
   
  
 0.750
gpatch1
G patch domain-containing 1.
    
 
 0.724
dldh
Dihydrolipoyl dehydrogenase.
   
    0.722
nom1
Nucleolar protein with MIF4G domain 1.
      
 0.694
zgc:91910
Zgc:91910.
      
 0.692
znf706
Zinc finger protein 706.
      
 0.692
prpf18
Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing.
    
 
 0.689
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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