STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dyrk1bDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1B. (751 aa)    
Predicted Functional Partners:
dcaf7
Ddb1 and cul4-associated factor 7.
   
 
 0.972
rnf169
E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage.
   
 
 0.734
foxk1
Forkhead box K1.
    
 
 0.658
ctbp2a
C-terminal-binding protein 2a.
    
 
 0.614
lin52
Protein lin-52 homolog.
   
 
 0.593
rbl2
Retinoblastoma-like 2 (p130).
   
 
 0.580
smad3a
Mothers against decapentaplegic homolog.
   
 
 0.494
lin54
Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA; Belongs to the lin-54 family.
   
 
 0.490
plk1
Serine/threonine-protein kinase PLK.
   
 
0.488
lim2.4
Lens intrinsic membrane protein 2.4.
      
 0.482
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.