nek1 protein (Danio rerio) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

nek1

NIMA-related kinase 1. (1200 aa)

Predicted Functional Partners:

als2a

0.874

tctex1d2

0.798

chchd10

0.772

nek2

0.761

cfap410

0.742

DYNC2H1

0.737

setx

0.726

dlgap5

0.715

ccnf

0.711

pacrg

0.686

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DYNC2H1	nek1	ENSDARP00000152917	ENSDARP00000030937	Dynein cytoplasmic 2 heavy chain 1.	NIMA-related kinase 1.	0.737
DYNC2H1	tctex1d2	ENSDARP00000152917	ENSDARP00000152151	Dynein cytoplasmic 2 heavy chain 1.	Tctex1 domain-containing 2.	0.817
als2a	ccnf	ENSDARP00000097741	ENSDARP00000141877	Alsin Rho guanine nucleotide exchange factor ALS2 a.	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	0.713
als2a	cfap410	ENSDARP00000097741	ENSDARP00000142299	Alsin Rho guanine nucleotide exchange factor ALS2 a.	Cilia and flagella-associated protein 410.	0.901
als2a	chchd10	ENSDARP00000097741	ENSDARP00000005265	Alsin Rho guanine nucleotide exchange factor ALS2 a.	Coiled-coil-helix-coiled-coil-helix domain-containing 10.	0.720
als2a	nek1	ENSDARP00000097741	ENSDARP00000030937	Alsin Rho guanine nucleotide exchange factor ALS2 a.	NIMA-related kinase 1.	0.874
als2a	pacrg	ENSDARP00000097741	ENSDARP00000106202	Alsin Rho guanine nucleotide exchange factor ALS2 a.	PARK2 co-regulated.	0.448
als2a	setx	ENSDARP00000097741	ENSDARP00000124379	Alsin Rho guanine nucleotide exchange factor ALS2 a.	Senataxin.	0.912
ccnf	als2a	ENSDARP00000141877	ENSDARP00000097741	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	Alsin Rho guanine nucleotide exchange factor ALS2 a.	0.713
ccnf	chchd10	ENSDARP00000141877	ENSDARP00000005265	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	Coiled-coil-helix-coiled-coil-helix domain-containing 10.	0.735
ccnf	dlgap5	ENSDARP00000141877	ENSDARP00000066410	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	Discs, large (Drosophila) homolog-associated protein 5.	0.471
ccnf	nek1	ENSDARP00000141877	ENSDARP00000030937	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	NIMA-related kinase 1.	0.711
ccnf	nek2	ENSDARP00000141877	ENSDARP00000020452	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	NIMA (Never in mitosis gene a)-related kinase 2.	0.540
ccnf	setx	ENSDARP00000141877	ENSDARP00000124379	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	Senataxin.	0.556
cfap410	als2a	ENSDARP00000142299	ENSDARP00000097741	Cilia and flagella-associated protein 410.	Alsin Rho guanine nucleotide exchange factor ALS2 a.	0.901
cfap410	nek1	ENSDARP00000142299	ENSDARP00000030937	Cilia and flagella-associated protein 410.	NIMA-related kinase 1.	0.742
cfap410	tctex1d2	ENSDARP00000142299	ENSDARP00000152151	Cilia and flagella-associated protein 410.	Tctex1 domain-containing 2.	0.641
chchd10	als2a	ENSDARP00000005265	ENSDARP00000097741	Coiled-coil-helix-coiled-coil-helix domain-containing 10.	Alsin Rho guanine nucleotide exchange factor ALS2 a.	0.720
chchd10	ccnf	ENSDARP00000005265	ENSDARP00000141877	Coiled-coil-helix-coiled-coil-helix domain-containing 10.	Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase; Belongs to the cyclin family. Cyclin AB subfamily.	0.735
chchd10	nek1	ENSDARP00000005265	ENSDARP00000030937	Coiled-coil-helix-coiled-coil-helix domain-containing 10.	NIMA-related kinase 1.	0.772

page 1 of 3

Server load: low (18%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2026

Credits

Access

Info

About