Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prkchaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (712 aa)    
Predicted Functional Partners:
ankha
ANKH inorganic pyrophosphate transport regulator a.
      
 0.994
kank1b
KN motif and ankyrin repeat domains 1b.
    
 0.988
braf
B-Raf proto-oncogene, serine/threonine kinase.
    
  0.898
araf
A-Raf proto-oncogene, serine/threonine kinase.
    
  0.898
znf148
Zinc finger protein 148; Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development. Belongs to the krueppel C2H2-type zinc-finger protein family.
    
 
 0.836
trpv6
Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.
   
 0.773
raf1b
Raf-1 proto-oncogene, serine/threonine kinase b.
    
  0.757
raf1a-2
Raf-1 proto-oncogene, serine/threonine kinase a.
    
  0.757
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a.
    
  0.757
mapk9
Mitogen-activated protein kinase.
    
 0.744
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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