node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BOLA2 | abcb7 | ENSDARP00000146412 | ENSDARP00000085602 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | 0.478 |
BOLA2 | ciapin1 | ENSDARP00000146412 | ENSDARP00000105419 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.977 |
BOLA2 | fdx1 | ENSDARP00000146412 | ENSDARP00000113657 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | Ferredoxin 1. | 0.529 |
BOLA2 | fdx2 | ENSDARP00000146412 | ENSDARP00000131094 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.455 |
BOLA2 | glrx3 | ENSDARP00000146412 | ENSDARP00000133690 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | Glutaredoxin 3; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). | 0.997 |
BOLA2 | mms19 | ENSDARP00000146412 | ENSDARP00000126941 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). | 0.740 |
BOLA2 | ndor1 | ENSDARP00000146412 | ENSDARP00000156852 | Zgc:112271 protein; Belongs to the BolA/IbaG family. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1. In the N-terminal section; belongs to the flavodoxin family. | 0.762 |
abcb7 | BOLA2 | ENSDARP00000085602 | ENSDARP00000146412 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Zgc:112271 protein; Belongs to the BolA/IbaG family. | 0.478 |
abcb7 | ciapin1 | ENSDARP00000085602 | ENSDARP00000105419 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.801 |
abcb7 | fdx1 | ENSDARP00000085602 | ENSDARP00000113657 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Ferredoxin 1. | 0.731 |
abcb7 | fdx2 | ENSDARP00000085602 | ENSDARP00000131094 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.744 |
abcb7 | glrx3 | ENSDARP00000085602 | ENSDARP00000133690 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | Glutaredoxin 3; Together with bola2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). | 0.890 |
abcb7 | mms19 | ENSDARP00000085602 | ENSDARP00000126941 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). | 0.881 |
abcb7 | ndor1 | ENSDARP00000085602 | ENSDARP00000156852 | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1. In the N-terminal section; belongs to the flavodoxin family. | 0.778 |
cbsa | cbsb | ENSDARP00000053931 | ENSDARP00000111387 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.901 |
cbsa | flad1 | ENSDARP00000053931 | ENSDARP00000094012 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the N-terminal section; belongs to the MoaB/Mog family. | 0.767 |
cbsa | ndor1 | ENSDARP00000053931 | ENSDARP00000156852 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1. In the N-terminal section; belongs to the flavodoxin family. | 0.711 |
cbsb | cbsa | ENSDARP00000111387 | ENSDARP00000053931 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.901 |
cbsb | flad1 | ENSDARP00000111387 | ENSDARP00000094012 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the N-terminal section; belongs to the MoaB/Mog family. | 0.767 |
cbsb | ndor1 | ENSDARP00000111387 | ENSDARP00000156852 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of ciapin1. In the N-terminal section; belongs to the flavodoxin family. | 0.711 |