| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| atf7ip | mbd1b | ENSDARP00000125013 | ENSDARP00000031774 | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity); Belongs to the MCAF family. | Methyl-CpG-binding domain protein 1b. | 0.727 |
| atf7ip | setdb1b | ENSDARP00000125013 | ENSDARP00000136505 | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing histone methyltransferase activity. May belong to a complex that represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (By similarity); Belongs to the MCAF family. | Histone-lysine N-methyltransferase SETDB1-B; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-re [...] | 0.972 |
| cfap161 | cfap20 | ENSDARP00000011815 | ENSDARP00000140557 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | 0.961 |
| cfap161 | cfap45 | ENSDARP00000011815 | ENSDARP00000148801 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Cilia and flagella-associated protein 45. | 0.829 |
| cfap161 | mbd1b | ENSDARP00000011815 | ENSDARP00000031774 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Methyl-CpG-binding domain protein 1b. | 0.685 |
| cfap161 | tekt2 | ENSDARP00000011815 | ENSDARP00000059357 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Tektin 2 (testicular). | 0.936 |
| cfap161 | tekt3 | ENSDARP00000011815 | ENSDARP00000127387 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Tektin 3. | 0.909 |
| cfap20 | cfap161 | ENSDARP00000140557 | ENSDARP00000011815 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.961 |
| cfap20 | cfap45 | ENSDARP00000140557 | ENSDARP00000148801 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | Cilia and flagella-associated protein 45. | 0.923 |
| cfap20 | mbd1b | ENSDARP00000140557 | ENSDARP00000031774 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | Methyl-CpG-binding domain protein 1b. | 0.720 |
| cfap20 | tekt2 | ENSDARP00000140557 | ENSDARP00000059357 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | Tektin 2 (testicular). | 0.909 |
| cfap20 | tekt3 | ENSDARP00000140557 | ENSDARP00000127387 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | Tektin 3. | 0.929 |
| cfap45 | cfap161 | ENSDARP00000148801 | ENSDARP00000011815 | Cilia and flagella-associated protein 45. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.829 |
| cfap45 | cfap20 | ENSDARP00000148801 | ENSDARP00000140557 | Cilia and flagella-associated protein 45. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. | 0.923 |
| cfap45 | mbd1b | ENSDARP00000148801 | ENSDARP00000031774 | Cilia and flagella-associated protein 45. | Methyl-CpG-binding domain protein 1b. | 0.754 |
| cfap45 | tekt2 | ENSDARP00000148801 | ENSDARP00000059357 | Cilia and flagella-associated protein 45. | Tektin 2 (testicular). | 0.865 |
| cfap45 | tekt3 | ENSDARP00000148801 | ENSDARP00000127387 | Cilia and flagella-associated protein 45. | Tektin 3. | 0.782 |
| chaf1a | mbd1b | ENSDARP00000101598 | ENSDARP00000031774 | Chromatin assembly factor 1 subunit A; May be involved in chromatin assembly in DNA replication and DNA repair; Belongs to the CHAF1A family. | Methyl-CpG-binding domain protein 1b. | 0.844 |
| chaf1a | mbd3a | ENSDARP00000101598 | ENSDARP00000082941 | Chromatin assembly factor 1 subunit A; May be involved in chromatin assembly in DNA replication and DNA repair; Belongs to the CHAF1A family. | Methyl-CpG-binding domain protein 3a. | 0.529 |
| chaf1a | setdb1b | ENSDARP00000101598 | ENSDARP00000136505 | Chromatin assembly factor 1 subunit A; May be involved in chromatin assembly in DNA replication and DNA repair; Belongs to the CHAF1A family. | Histone-lysine N-methyltransferase SETDB1-B; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-re [...] | 0.631 |
