Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
Experiments
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[Homology]
Score
ormdl3ORM1-like protein 3; Negative regulator of sphingolipid synthesis; Belongs to the ORM family. (153 aa)    
Predicted Functional Partners:
sptssa
Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSA subfamily.
    
 0.980
sptlc2b
Serine palmitoyltransferase, long chain base subunit 2b.
    
 0.955
sptssb
Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (By similarity). Belongs to the SPTSS family. SPTSSB subfamily.
     
 0.937
ormdl1
ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family.
  
 
0.904
ormdl2
ORM1-like protein; Negative regulator of sphingolipid synthesis.
  
  
0.901
sptlc1
Serine palmitoyltransferase, long chain base subunit 1.
    
 
 0.825
sptlc3
Serine palmitoyltransferase, long chain base subunit 3.
    
 
 0.653
sptlc2a
Serine palmitoyltransferase, long chain base subunit 2a.
    
 
 0.642
aff3
AF4/FMR2 family, member 3.
    
 
 0.602
ism1
Isthmin-1; May specifically influence certain angiogenesis process.
    
 
 0.573
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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