Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rfx4Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family. (735 aa)    
Predicted Functional Partners:
ttll6
Tubulin polyglutamylase ttll6; Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Required for formation of olfactory cilia. Generates long side-chains (By similarity); Belongs to the tubulin--tyrosine ligase family.
      
 0.753
foxj1a
Forkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia.
    
 
 0.743
rfxap
Regulatory factor X-associated protein.
    
 0.735
sgsm1a
Small G protein-signaling modulator 1a.
      
 0.662
rfxank
Regulatory factor X-associated ankyrin-containing protein.
    
 0.656
mnx1
Motor neuron and pancreas homeobox 1.
      
 0.647
chek2
Checkpoint kinase 2.
    
 0.643
ift172
Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia.
    
 
 0.642
mab21l3
Protein mab-21-like 3; Belongs to the mab-21 family.
      
 0.637
tbx20
T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.
   
  
 0.628
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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