node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSDARP00000153311 | chd6 | ENSDARP00000153311 | ENSDARP00000032370 | Helicase ATP-binding domain-containing protein. | Chromodomain helicase DNA-binding protein 6. | 0.584 |
ENSDARP00000153311 | fancm | ENSDARP00000153311 | ENSDARP00000131968 | Helicase ATP-binding domain-containing protein. | FA complementation group M. | 0.991 |
chd6 | ENSDARP00000153311 | ENSDARP00000032370 | ENSDARP00000153311 | Chromodomain helicase DNA-binding protein 6. | Helicase ATP-binding domain-containing protein. | 0.584 |
chd6 | fancm | ENSDARP00000032370 | ENSDARP00000131968 | Chromodomain helicase DNA-binding protein 6. | FA complementation group M. | 0.584 |
chd6 | med16 | ENSDARP00000032370 | ENSDARP00000059751 | Chromodomain helicase DNA-binding protein 6. | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.584 |
chd6 | rtf1 | ENSDARP00000032370 | ENSDARP00000110578 | Chromodomain helicase DNA-binding protein 6. | RTF1 homolog, Paf1/RNA polymerase II complex component. | 0.637 |
chd6 | setd2 | ENSDARP00000032370 | ENSDARP00000114457 | Chromodomain helicase DNA-binding protein 6. | SET domain-containing 2, histone lysine methyltransferase. | 0.579 |
chd6 | ssrp1a | ENSDARP00000032370 | ENSDARP00000114529 | Chromodomain helicase DNA-binding protein 6. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.623 |
chd6 | ssrp1b | ENSDARP00000032370 | ENSDARP00000118787 | Chromodomain helicase DNA-binding protein 6. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.623 |
chd6 | supt16h | ENSDARP00000032370 | ENSDARP00000111043 | Chromodomain helicase DNA-binding protein 6. | SPT16 homolog, facilitates chromatin-remodeling subunit. | 0.652 |
chd6 | supt4h1 | ENSDARP00000032370 | ENSDARP00000147232 | Chromodomain helicase DNA-binding protein 6. | Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity). | 0.609 |
chd6 | supt5h | ENSDARP00000032370 | ENSDARP00000062675 | Chromodomain helicase DNA-binding protein 6. | Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] | 0.637 |
fancm | ENSDARP00000153311 | ENSDARP00000131968 | ENSDARP00000153311 | FA complementation group M. | Helicase ATP-binding domain-containing protein. | 0.991 |
fancm | chd6 | ENSDARP00000131968 | ENSDARP00000032370 | FA complementation group M. | Chromodomain helicase DNA-binding protein 6. | 0.584 |
med16 | chd6 | ENSDARP00000059751 | ENSDARP00000032370 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Chromodomain helicase DNA-binding protein 6. | 0.584 |
rtf1 | chd6 | ENSDARP00000110578 | ENSDARP00000032370 | RTF1 homolog, Paf1/RNA polymerase II complex component. | Chromodomain helicase DNA-binding protein 6. | 0.637 |
rtf1 | setd2 | ENSDARP00000110578 | ENSDARP00000114457 | RTF1 homolog, Paf1/RNA polymerase II complex component. | SET domain-containing 2, histone lysine methyltransferase. | 0.768 |
rtf1 | ssrp1a | ENSDARP00000110578 | ENSDARP00000114529 | RTF1 homolog, Paf1/RNA polymerase II complex component. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.971 |
rtf1 | ssrp1b | ENSDARP00000110578 | ENSDARP00000118787 | RTF1 homolog, Paf1/RNA polymerase II complex component. | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.957 |
rtf1 | supt16h | ENSDARP00000110578 | ENSDARP00000111043 | RTF1 homolog, Paf1/RNA polymerase II complex component. | SPT16 homolog, facilitates chromatin-remodeling subunit. | 0.991 |