Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sppl2Signal peptide peptidase-like 2. (555 aa)    
Predicted Functional Partners:
lat
Linker for activation of T cells.
      
 0.839
tnfa
Tumor necrosis factor a (TNF superfamily, member 2).
     
  0.750
tnfsf13
TNF superfamily member 13; Belongs to the tumor necrosis factor family.
      
 0.720
spata18
Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...]
      
 0.696
sdc2
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
      
 0.662
spata20
Spermatogenesis-associated 20.
      
 0.606
spryd4
SPRY domain-containing 4.
      
 0.604
mrps24
28S ribosomal protein S24, mitochondrial; Belongs to the universal ribosomal protein uS3 family.
      
 0.603
zdhhc6
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
      
 0.602
hyi
Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.
      
 0.602
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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