| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| nadk2 | nadkb | ENSDARP00000112992 | ENSDARP00000119147 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD kinase b. | 0.986 |
| nadk2 | nadsyn1 | ENSDARP00000112992 | ENSDARP00000137823 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.983 |
| nadk2 | nnt | ENSDARP00000112992 | ENSDARP00000032730 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Nicotinamide nucleotide transhydrogenase. | 0.980 |
| nadk2 | nudt12 | ENSDARP00000112992 | ENSDARP00000139063 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Nudix (nucleoside diphosphate-linked moiety X)-type motif 12. | 0.956 |
| nadk2 | sarm1 | ENSDARP00000112992 | ENSDARP00000014434 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (By similarity). Wallerian degeneration is triggerred by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADP [...] | 0.950 |
| nadk2 | sirt1 | ENSDARP00000112992 | ENSDARP00000088981 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Sirtuin 1. | 0.944 |
| nadk2 | sirt2 | ENSDARP00000112992 | ENSDARP00000003412 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] | 0.944 |
| nadk2 | sirt3 | ENSDARP00000112992 | ENSDARP00000051972 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.945 |
| nadk2 | sirt5 | ENSDARP00000112992 | ENSDARP00000040792 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. | 0.948 |
| nadk2 | sirt7 | ENSDARP00000112992 | ENSDARP00000157213 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | Sirtuin 7. | 0.944 |
| nadkb | nadk2 | ENSDARP00000119147 | ENSDARP00000112992 | NAD kinase b. | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. | 0.986 |
| nadkb | nadsyn1 | ENSDARP00000119147 | ENSDARP00000137823 | NAD kinase b. | Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. | 0.970 |
| nadkb | nnt | ENSDARP00000119147 | ENSDARP00000032730 | NAD kinase b. | Nicotinamide nucleotide transhydrogenase. | 0.979 |
| nadkb | nudt12 | ENSDARP00000119147 | ENSDARP00000139063 | NAD kinase b. | Nudix (nucleoside diphosphate-linked moiety X)-type motif 12. | 0.955 |
| nadkb | sarm1 | ENSDARP00000119147 | ENSDARP00000014434 | NAD kinase b. | NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (By similarity). Wallerian degeneration is triggerred by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADP [...] | 0.964 |
| nadkb | sirt1 | ENSDARP00000119147 | ENSDARP00000088981 | NAD kinase b. | Sirtuin 1. | 0.963 |
| nadkb | sirt2 | ENSDARP00000119147 | ENSDARP00000003412 | NAD kinase b. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] | 0.949 |
| nadkb | sirt3 | ENSDARP00000119147 | ENSDARP00000051972 | NAD kinase b. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.949 |
| nadkb | sirt5 | ENSDARP00000119147 | ENSDARP00000040792 | NAD kinase b. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. | 0.949 |
| nadkb | sirt7 | ENSDARP00000119147 | ENSDARP00000157213 | NAD kinase b. | Sirtuin 7. | 0.949 |
