Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
khsrpKH-type-splicing regulatory protein. (666 aa)    
Predicted Functional Partners:
puf60b
Poly(U)-binding-splicing factor PUF60-B; DNA- and RNA-binding protein, involved in transcription repression and pre-mRNA splicing.
   
 
 0.879
smn1
Survival motor neuron protein 1; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of tmem41b mRNA. Required for the maturation of motor neuron axonal branches and dendrites.
    
 
 0.827
fubp3
Far upstream element (FUSE)-binding protein 3.
   
   0.814
puf60a
Poly-U-binding-splicing factor a.
   
 
 0.802
drosha
Drosha ribonuclease III.
   
 
 0.768
hnrnpa1b
Heterogeneous nuclear ribonucleoprotein A1b.
   
 
 0.746
hnrnpm
Heterogeneous nuclear ribonucleoprotein M.
   
 
 0.745
hnrnpaba
Heterogeneous nuclear ribonucleoprotein A/Ba.
   
 
 0.742
tia1
TIA1 cytotoxic granule-associated RNA-binding protein.
   
 
 0.729
khdc4
KH homology domain-containing protein 4; RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
      
 0.720
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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